With a place in the quarter finals at stake, this crunch tie between the blues and the Parisians will be settled at Stamford bridge.
Over the previous two seasons, one has progressed with Chelsea claiming victory in the 2013/2014 season while PSG progressed in the 2014/2015 season.
However, the team from Paris are clearly favourites with the blues trailing 2:1 on aggregate from the first leg.
Both teams played out their matches at the weekend with one eye on this fixture, Diego Costa was rested while Fabregas was a second half substitute as the blues drew with Stoke City. Paris St Germain were however frustrated by Montpellier in a goalless draw.
The blues have never lost a domestic match under Guus and will be hoping to pull off a shock considering they are underdogs playing in front of their fans. In -form blues striker Diego Costa as well as Fabregas, Eden Hazard and Willian will all be expected to feature from the start. The match comes too early for Pedro and the blues captain John Terry who are still nursing injuries. Kenedy will be assessed to see of he will be able to play a part.
The Parisians are sweating over the fitness of Angel Di Maria and Marco Veratti while Aurier is also a doubt.
A 1:0 win for the blues will secure passage into the next round while any sort of draw will see PSG progress at the expense of Chelsea.
19:45GMT is kickoff time. Keep your eye on this one.